1. INTRODUCTION 5 -- 2. OBJECTIVES AND SCOPE OF THIS GUIDELINE 5 -- 3. METHODS ... 6 -- 3.1. SYSTEMATIC REVIEW OF THE LITERATURE 6 -- 3.2. FORMULATION OF RECOMMENDATIONS 7 -- 4. CLINICAL RECOMMENDATIONS 9 -- 4.1. DIAGNOSIS AND STAGING 9 -- 4.1.1. Patient information ... 9 -- 4.1.2. Biopsy 9 -- 4.1.3. Conventional imaging techniques 10 -- 4.1.4. PET scan 10 -- 4.1.5. Other staging interventions 10 -- 4.1.6. HPV testing ... 11 -- 4.2. TREATMENT OF PRIMARY NON-METASTATIC ORAL CAVITY CANCER 11 -- 4.2.1. Multidisciplinary treatment 11 -- 4.2.2. Surgical treatment 11 -- 4.2.3. Radiotherapy 12 -- 4.2.4. Induction chemotherapy 13 -- 4.2.5. Reconstructive surgery ... 13 -- 4.2.6. Management of the neck lymph nodes 14 -- 4.2.7. Neck dissection after chemoradiotherapy 14 -- 4.3. HISTOPATHOLOGY ... 15 -- 4.4. TREATMENT OF METASTATIC OR RECURRENT DISEASE NOT ELIGIBLE FOR CURATIVE TREATMENT 15 -- 4.5. LOCOREGIONAL RECURRENCE 16 -- 4.6. FOLLOW-UP 16 -- 4.7. REHABILITATION AND SUPPORTIVE TREATMENT 17 -- 4.7.1. Dental rehabilitation 17 -- 4.7.2. Speech and swallowing rehabilitation 17 -- 4.7.3. Nutritional therapy 18 -- 4.7.4. Psychosocial counselling and support 18 -- 5. IMPLEMENTATION AND UPDATING OF THE GUIDELINE 19 -- 5.1. IMPLEMENTATION 19 -- 5.2. MONITORING THE QUALITY OF CARE 19 -- 5.3. GUIDELINE UPDATE 19 -- POLICY RECOMMENDATIONS 20