Introduction: During the dialysis session, hypersensitivity reactions to the dialyzer may occur. Clinically, these conditions can vary in severity, from pruritus, erythema, and facial edema to more severe conditions such as dyspnea, bronchospasm, tachypnea, cyanosis, shock, and cardiac arrest. We present an unusual case of repeated anaphylactic shock, possibly caused by the use of a dialyzer with a helixone membrane. Clinical case: 60-year-old hypertensive and type 2 diabetic woman who presented uremia with hypervolemia and underwent dialysis treatment in the hemodialysis program. During the sixth session, she witnessed cardiorespiratory arrest, with recovery of spontaneous circulation after advanced cardiopulmonary resuscitation. Management: Required management in intensive care with intravenous nitroprusside and intubation with mechanical ventilation. Evolution: Given a new treatment, he once again developed hemodynamic instability with hypotension at the beginning of treatment. She was transferred to the peritoneal dialysis program. Conclusion: An anaphylactic reaction to helixone associated with hypotension and anaphylactic shock is reported.