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Inclusive Reaction by Swellable Clay Minerals. III

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1991Publisher:Japan Oil Chemists' SocietyJournal:Journal of Japan Oil Chemists' Society, volume 40, pages 491-496 (eissn: 1884-2003,

Authors: Michiro Yamaguchi; Yoshimaru Kumano; Shinji C O Shiseido Labor Tobe;

doi: 10.5650/jos1956.40.491

Inclusive Reaction by Swellable Clay Minerals. III

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Abstract

The solubilization behavior of a poorly water-soluble drug (griseofulvin : GF) was examined using swellable clay minerals. The solubility of GF in pure water markedly increased by complex formation with clay minerals. GF in the complex was completely solubilized in pure water for the samples at a GF/clay mineral ratio less than 10 wt %. The formation of the complex was due to depression of the crystal growth of GF based on strong host-guest interactions between GF and clay minerals. The greatest solubility was achieved by the complex produced for the system GF/synthesized clay mineral.

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