To evaluate the quality of orodispersible famotidine tablets (15 versions of 8 preparations comprising the original product and 7 generic products), a hardness test, dropping shock test, abrasion test, and bitter taste test were conducted. Large differences were observed in the hardness, dropping shock, and abrasion tests among the preparations. In the dropping shock and abrasion tests, however, no change was observed in the appearance of some preparations but the tablet weight decreased or tablets broke into pieces with some of them. In the taste test, 4 preparations were found to be masked sufficiently against bitter taste, but 4 preparations were not. These results suggest that some of the generic products were superior in quality to the original product and some were inferior. It is therefore necessary to adequately evaluate differences in quality when selecting generic products.