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İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi
Article . 2016 . Peer-reviewed
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İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi
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Ruxolitinib and effect mechanisms

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 06 Jun 2016Publisher:Baycinar Tibbi YayincilikJournal:Istanbul Bilim University Florence Nightingale Journal of Medicine, volume 2, pages 153-157 (issn: 2149-4401, eissn: 2547-9466, Copyright policy )
Authors: Bakiye Goker Bagca; Cigir Biray Avci;

doi: 10.5606/fng.btd.2016.028

Ruxolitinib and effect mechanisms

Abstract

Ruxolitinib JAK1 ve JAK2 tirozin kinazlarinin inhibitorudur. Jakafi adiyla piyasaya surulen ruxolitinib, miyelofibroz tedavisinde onaylanan ilk kimyasalajan olarak 2011 yilindan beri kullanilmaktadir. Miyeloproliferatif neoplazmlar (MPN) Philadelphia kromozom (Ph) pozitif ve negatif hastaliklari icerir.2001 yilinda imatinib tirozin kinazinin gelistirilmesinden bu yana Ph+ kronik miyeloid losemi tedavisinde tirozin kinaz inhibitorlerine odaklanilmistir.Direnc gelisimine bagli olarak yeni nesil tirozin kinaz inhibitorleri gelistirilmis ve kullanilmistir. Bunun tersine Ph- MPN’lerde hedefli tedavi dahaaz anlasilmis guncel bir konudur. Ph-MPN’ler genellikle JAK-STAT yolaginin mutasyonlarindan kaynaklanir. Bu derlemede hem Ph+ hem de Ph-MPN’lerde en guncel tirozin kinaz inhibitoru olan ruxolitinib ile olusturulabilecek hedefli tedavi secenekleri incelenmistir.

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
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