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Folia Histochemica et Cytobiologica
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https://dx.doi.org/10.5603/fhc...
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CD163 and its role in inflammation

descriptionPublicationkeyboard_double_arrow_right Article 28 Oct 2011Publisher:VM Media SP. zo.o VM Group SKJournal:Folia Histochemica et Cytobiologica, volume 49, pages 365-374 (issn: 0239-8508, eissn: 1897-5631, Copyright policy )
Authors: Lech Chyczewski; Marek Bielecki; Emila Sławińska; Richard Silver; Krzysztof Kowal; Otylia Kowal-Bielecka;

doi: 10.5603/fhc.2011.0052

pmid: 22038213

CD163 and its role in inflammation

Abstract

Mononuclear phagocytes represent a heterogeneous population of cells with individual subpopulations exerting different pro- or anti-inflammatory functions. CD163 is a monocyte/macrophage specific marker expressed predominantly on cells which possess strong anti-inflammatory potential. The expression of CD163 is strongly induced by anti-inflammatory mediators such as glucocorticoids and interleukin-10, while being inhibited by pro-inflammatory mediators such as interferon-gamma. CD163-expressing mononuclear phagocytes, as well as soluble CD163, may both take part in downregulating an inflammatory response. It seems, therefore, that CD163 may be an interesting target for therapeutic modulation of the inflammatory response.

Related Organizations
Keywords

Inflammation, QH573-671, Macrophages, Antigens, Differentiation, Myelomonocytic, Receptors, Cell Surface, Adaptive Immunity, Immunity, Innate, Monocytes, CD163 Antigen, inflammation, Antigens, CD, Animals, Cytokines, Humans, CD163, Chemokines, Cytology, Biomarkers

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    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 116
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
116
Top 1%
Top 10%
Top 10%
gold