Most of the patients with hypertension require combined therapy in order to achieve target blood pressure. Antihyper­tensive agents should improve compliance with medical recommendations and allow achieving therapeutic goals. The combination of perindopril with indapamide and amlodipine is particularly recommended in population of hypertensive patients with metabolic complications because of favourable, neutral effect on blood glucose and cholesterol level. This combination has proven hypotensive effect in group of patients with difficult-to-control hypertension.