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Kocatepe Veterinary Journal
Article . 2016 . Peer-reviewed
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Kocatepe Veterinary Journal
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Epidermal Growth Factor

Epidermal Büyüme Faktörü
descriptionPublicationkeyboard_double_arrow_right Article 19 Sep 2016Publisher:Kocatepe Veteriner DergisiJournal:Kocatepe Veterinary Journal, volume 9, pages 215-225 (issn: 1308-1594, eissn: 2147-6853, Copyright policy )
Authors: Filiz Kazak; Gul Fatma Yarim;

doi: 10.5578/kvj.24183

Epidermal Growth Factor

Abstract

Epidermal buyume faktoru, hucrelerin bolunmesi, farklilasmasi, yasamasi, cogalmasi, buyumesi ve hucre gocunu uyaran protein yapida bir buyume faktoru olup, organizmadaki pek cok fizyolojik ve patolojik surecte rol almaktadir. EGF, anti-enflamatuar, anti-apoptotik, norotrofik ve noroprotektif etkilere sahiptir. Epidermal buyume faktoru reseptorleri akciger, mide, duodenum, pankreas, bobrek, hipofiz bezi, tiroid bezi, meme bezi, yumurtalik, uterus, plasenta, kornea ve gliya hucrelerinde bulunmaktadir. Trombositler, makrofajlar, monositler ve fibroblastlar da epidermal buyume faktoru kaynagidir. Epidermal buyume faktoru, epidermal buyume faktoru reseptorune baglanarak, MAPK, ERK 1/2, PI3K-Akt, PLC-γ, JAK/STAT hucre ici sinyalizasyon yolaklarini aktive ederek etki etmektedir. Epidermal buyume faktoru etkilerini baslica sindirim sistemi, ureme sistemi ve sinir sistemi uzerinde gostermektedir. Fibroblastlarin, kerotinisitlerin, vaskuler endotel hucrelerinin buyumesini ve cogalmasini uyarici etkisi nedeniyle, ozellikle yaralarin tedavisinde epidermal buyume faktoru uygulamalari basari saglamaktadir. Bu derlemenin amaci, EGF’nin yapisi, kaynaklari, reseptoru, etki mekanizmasi, etkileri ve tedavide kullanimini ozetlemektir.

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    		 2
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Average
Average
Average
gold