Trap-Neuter-Return (TNR) is well-established in many countries and increasingly considered to be the most effective and humane way to manage feral and stray cat populations. Nonetheless, it confronts major challenges everywhere it is practiced. Although Switzerland has an impressive TNR system carried out mainly by private, non-profit organizations and individual citizens, the management of feline overpopulation could be strengthened by improvements on a number of fronts, including legal and governance changes, education and modifications in mentality, and operational adjustments such as data management and analysis. TNR faces a number of common challenges worldwide, and given that it is still relatively young, lessons from one country can be valuable for another. Because little has been written about TNR in Switzerland, this article seeks to fill this gap by providing a preliminary analysis of the case through the prism of existing analytical work done on TNR in other countries.