Patients with recurrent infections generate a large number of outpatient infectious disease referrals. While the differential diagnosis is vast, primary immunodeficiency is a consideration, but frequently overlooked. A subset of these maladies is Specific Antibody Deficiency. By definition, this diagnosis requires levels of both quantitative immunoglobulins and IgG subsets to be normal. Therapy is available, making identification of this immunodeficiency critical.