Stevens-Johnson Syndrome (SJS) is an antibody-mediated disease characterized by prodromal symptoms followed by severe mucocutaneous manifestations. The more severe form of SJS is Toxic Epidermal Necrolysis (TEN), which causes an inflammatory response resulting in keratinocyte necrosis and perivascular lymphocyte infiltration. The incidence of SJS is said to be 1 - 6 per one million people per year, while the incidence of TEN is only 0.4 - 1.2 per one million people per year. So far, similar studies on SJS/TEN cases in Indonesia are minimal as this disease is one of the rare cases. SJS/TEN is an emergency with high mortality and disability. Moderate to severe cases have a mortality rate of 5-15%. In this case, the patient was a 62-year-old male. Based on history and physical examination, the patient was diagnosed with Stevens-Johnson Syndrome (SJS). In the dermatologic status of the manus region dextra and sinistra, sagging bulla was found, and in the anterior thorax region, erosive lesions due to ruptured bulla were found. In the medialis femoris region dextra, multiple erythematous, annular macular lesions were found. There were erosions and crusts on the labial and genital regions.