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Pharmaceutical Methods
Article . 2016 . Peer-reviewed
Data sources: Crossref
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ZENODO
Article . 2016
License: CC BY
Data sources: ZENODO
ZENODO
Article . 2016
License: CC BY
Data sources: Datacite
ZENODO
Article . 2016
License: CC BY
Data sources: Datacite
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Development and Characterization of Buccal Film of Candesartan

Authors: Malpure, Dipak Rajaram; Deore, Sharada Laxman;

Development and Characterization of Buccal Film of Candesartan

Abstract

Candesartan is potent antihypertensive drug of class angiotensin II receptor antagonist. But it exhibits poor water solubility and extensive first pass metabolism. Present research deals with development of candesartan buccal film. Optimisation of buccal film was done by design expert. Optimised concentration range selected for development of trial batches of candesaratanbuccal films. Mucoadhesivebuccal films of candesartan were prepared by solvent casting technique using chitosan, HPMC, gelatin and EDTA as permeation enhancer. Prepared buccal films evaluated for various pharmaceutical parameters, stability studies, in-vitro and ex-vivo evaluation parameters performed. In-vitroangiotensin II receptor antagonist studies were also performed. Results showed improved bioavaibility of candesartan through buccal films.

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    4
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
4
Average
Average
Average
gold