Background: Appropriate utilization of antimicrobial specialists is imperatively significant from clinical points. Present anti-microbial agents are one of very crucial for clinical consideration and assume a significant job profile, both in prophylaxis and treatment of irresistible illnesses. Not with standing, their abuse is an overall issue with the degree of the issue being more prominent in the developing nations. Objective: To observe the utilization of antimicrobials for prophylaxis and treatment among patients who have faced orthopedic medical procedure. Methodology: An imminent and observational examination was led on 130 clinical records of orthopedic patients who experienced medical procedure. Results: We have selected the data of 130 patients, comprises of 70 male and 60 female patients who underwent the orthopedic medical surgeries. It was observed that the most commonly used antimicrobials classes were cephalosporin’s (76.43%) and cefuroxime (67.40%), for prophylaxis and treatment, respectively. It was find out that almost half of cases for prophylaxis were inappropriate whereas around 73.07 % of antibiotics treatment neglected to hold fast to guidelines. Conclusion: Generally, this investigation includes the maximum numbers of patients from open reduction internal fixation (ORIF) and total hip replacement surgeries, respectively. The results of study observed the some degree of inappropriateness to some extent in case of surgical prophylaxis during orthopedic procedures. Key words: Antibiotics; Surgery; Prophylaxis; Investigation; Inappropriateness, ORIF.