Although corticosteroids are the main drugs for the treatment of AIHA, it should not be used in divided doses as subtitution treatment as of surrenal insufficiency; which has been applied previously; Rather it should be given at once around 6 a.m preferentially as Megadose methylprednisolone (MDMP) [4] intravenously or orally as desribed by us which was used in parttially one of the authors’ patient (30 mg/kg/day, for 3 days).