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Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi
Article . 2019 . Peer-reviewed
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Stem Cells

Authors: ÖREN, Hale;
Abstract

Kök hücreler kendini yenileyebilen ve spesifik hücre tiplerine dönüşebilen farklılaşmamış hücrelerdir. Kök hücreler vücutta bulundukları yere göre başlıca embriyonik kök hücreler ve erişkin kök hücreler olarak iki ana sınıfa ayrılır. Farklılaşma ve gelişme potansiyellerine göre ise kök hücreler totipotent, pluripotent, multipotent, oligopotent veya unipotent olabilirler. Çeşitli hastalıklarda tedavi amacıyla kullanılabilme ve rejeneratif tıptaki potansiyelleri nedeniyle embriyonik kök hücreler, indüklenmiş pluripotent kök hücreler, mezenkimal kök hücreler, hematopoietik kök hücreler ve kanser kök hücreleri ile farklı bilim alanlarında yapılmış çalışmalar vardır. Bu yazıda kök hücre tanımı, genel özellikleri ve klinikteki kullanımları üzerinde durulacaktır.

A stem cell is an undifferentiated cell that can self-renew itself and can commit to a specific cell type. Depending on their residency, stem cells are classified into two main categories as embryonic stem cells and adult stem cells. According to their differentiation and developmental potential, stem cells may be classified as totipotent, pluripotent, multipotent, and unipotent. The therapeutic potential in disease states and in regenerative medicine of embryonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, hematopoietic stem cells, and cancer stem cells have been studied in different scientific areas. In this review, the definition, common characteristics, and clinical use of different stem cells will be discussed.

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Keywords

Klinik Tıp Bilimleri, kök hücre;embriyonik kök hücre;indüklenmiş pluripotent kök hücre;mezenkimal kök hücre;hematopoietik kök hücre;kanser kök hücresi, Clinical Sciences, stem cell;embryonic stem cell;induced pluripotent stem cell;mesenchymal stem cell;hematopoietic stem cell;cancer stem cell

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    popularity
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
gold
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