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BMB Reports
Article . 2024 . Peer-reviewed
License: CC BY NC
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BMB Reports
Article . 2025
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Conference object . 2024
License: http://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (http://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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DNA regulatory element cooperation and competition in transcription

descriptionPublicationkeyboard_double_arrow_right Article , Conference object 03 Sep 2024 English Publisher:Korean Society for Biochemistry and Molecular Biology - BMB ReportsJournal:BMB Reports, volume 57, pages 509-520 (eissn: 1976-670X, Copyright policy )
Authors: Lee, Haram; Friedman, Meyer Joseph; Kim, Sang Bum; Oh, Soohwan;

doi: 10.5483/bmbrep.2024-0069

pmid: 39523506

pmc: PMC11693600

DNA regulatory element cooperation and competition in transcription

Abstract

Regulation of eukaryotic transcription is a complex process that enables precise temporal and spatial control of gene expression. Promoters, which are cis-regulatory elements (CREs) located proximal to the transcription start site (TSS), selectively integrate regulatory cues from distal CREs, or enhancers, and their associated transcriptional machinery. In this review, we discuss current knowledge regarding CRE cooperation and competition impacting gene expression, including features of enhancer-promoter, enhancer-enhancer, and promoter-promoter interplay. We also provide an overview of recent insights into the underlying molecular mechanisms that facilitate physical and functional interaction of regulatory elements, such as the involvement of enhancer RNAs and biomolecular condensates. [BMB Reports 2024; 57(12): 509-520].

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Keywords

Enhancer Elements, Genetic, Transcription, Genetic, Gene Expression Regulation, Humans, Animals, DNA, Regulatory Sequences, Nucleic Acid, Promoter Regions, Genetic, Invited Mini Review

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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gold