Translational control of mRNAs by 3'-Untranslated region binding proteins

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type , Report 30 Apr 2017 Japan English Publisher:Korean Society for Biochemistry and Molecular Biology - BMB ReportsJournal:BMB Reports, volume 50, pages 194-200 (issn: 1976-6696,

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Authors: Yamashita, Akio; Takeuchi, Osamu;

doi: 10.5483/bmbrep.2017.50.4.040

pmid: 28287067

pmc: PMC5437963

handle: 2433/227867

Translational control of mRNAs by 3'-Untranslated region binding proteins

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Abstract

Eukaryotic gene expression is precisely regulated at all points between transcription and translation. In this review, we focus on translational control mediated by the 3'-untranslated regions (UTRs) of mRNAs. mRNA 3'-UTRs contain cis-acting elements that function in the regulation of protein translation or mRNA decay. Each RNA binding protein that binds to these cis-acting elements regulates mRNA translation via various mechanisms targeting the mRNA cap structure, the eukaryotic initiation factor 4E (eIF4E)-eIF4G complex, ribosomes, and the poly (A) tail. We also discuss translation-mediated regulation of mRNA fate. [BMB Reports 2017; 50(4): 194-200].

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Japan

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Keywords

Translation, 3`-UTR, ranslation initiation, RNA-Binding Proteins, RNA binding protein, Invited Mini Review, Eukaryotic Initiation Factor-4E, Protein Biosynthesis, Animals, Humans, RNA, Messenger, Regulatory Elements, Transcriptional, Eukaryotic Initiation Factor-4G, Poly A, 3' Untranslated Regions, Ribosomes

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