HDAC3 acts as a negative regulator of angiogenesis

descriptionPublicationkeyboard_double_arrow_right Article 30 Apr 2014 English Publisher:Korean Society for Biochemistry and Molecular Biology - BMB ReportsJournal:BMB Reports, volume 47, pages 227-232 (issn: 1976-6696,

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Authors: Park, Deokbum; Park, Hyunmi; Kim, Youngmi; Kim, Hyuna; Jeoung, Dooil;

doi: 10.5483/bmbrep.2014.47.4.128

pmid: 24286308

pmc: PMC4163891

HDAC3 acts as a negative regulator of angiogenesis

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Abstract

Histone deacetylase-3 (HDAC3) is involved in cellular proliferation, apoptosis and transcriptional repression. However, the role of HDAC3 in angiogenesis remains unknown. HDAC3 negatively regulated the expression of angiogenic factors, such as VEGF and plasminogen activator inhibitor-1 (PAI-1). HDAC3 showed binding to promoter sequences of PAI-1. HDAC3 activity was necessary for the expression regulation of PAI-1 by HDAC3. VEGF decreased the expression of HDAC3, and the down-regulation of HDAC3 enhanced endothelial cell tube formation. HDAC3 negatively regulated tumor-induced angiogenic potential. We show the novel role of HDAC3 as a negative regulator of angiogenesis.

Related Organizations

UPRRP College of Natural Sciences
Puerto Rico
Kangwon National University
Korea (Republic of)

Keywords

Neovascularization, Pathologic, Human Umbilical Vein Endothelial Cells, Angiogenesis; Angiogenic factors; Anti cancer drug-resistance; Histonedeacetylase-3; Tumor-induced angiogenesis, Humans, Research Articles, Cells, Cultured, Histone Deacetylases, Histone Deacetylase 3

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