Modeled structure of trypanothione reductase of Leishmania infantum
Copyright policy )Modeled structure of trypanothione reductase of Leishmania infantum
Trypanothione reductase is an important target enzyme for structure-based drug design against Leishmania. We used homology modeling to construct a three-dimensional structure of the trypanothione reductase (TR) of Leishmania infantum. The structure shows acceptable Ramachandran statistics and a remarkably different active site from glutathione reductase(GR). Thus, a specific inhibitor against TR can be designed without interfering with host (human) GR activity.
Models, Molecular, Sequence Homology, Amino Acid, Protein Conformation, Molecular Sequence Data, Animals, NADH, NADPH Oxidoreductases, Amino Acid Sequence, Leishmania infantum
Models, Molecular, Sequence Homology, Amino Acid, Protein Conformation, Molecular Sequence Data, Animals, NADH, NADPH Oxidoreductases, Amino Acid Sequence, Leishmania infantum
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