The fully mechanized mining face with high mining height has always been a high-risk area for coal mine dust pollution. In order to further understand the spatiotemporal transport law of dust in the zoning of the high mining height fully mechanized mining face, the 122109 high mining height fully mechanized mining face of Caojiatan Coal Mine was taken as the research object. Numerical simulation method was used to simulate and analyze the dust transport situation of the 122109 fully mechanized mining machine drum single dust source, the hydraulic support moving frame single dust source, and the superposition of all dust sources in forward and backward wind cutting coal. The research results can guide the ventilation layout design in the early stage of the mine and the dust control in the comprehensive mining process, which is of great significance for the construction of safe and green mines.