Tarih Hypocalcemia is a clinical symptom of hypoparathyroidism, which is usually accompanied by distinctive signs and symptoms that vary depending on how severe and chronic the disease becomes. The aim of this study is to report on a case of severe hypocalcemia secondary to hypoparathyroidism in a postpartum woman. We present a case of a young woman with complaints of cramping legs and feet, tingling or burning in fingertips, toes, and lips, fatigue and weakness, twitching and spasms in muscles, particularly around the mouth, but also in hands and arms, painful menstrual periods, and depression, after the first delivery. She is successfully treated with calcium, calcitriol, magnesium, and levothyroxine. The idiopathic primary hypoparathyroidism, which is a rare condition, could be included in evaluating the differential diagnosis of hypocalcemia and depression in postpartum period.