Since its inception, the The OIChas been a pivotal force in combating defamation of religions. It has successfully mobilized international public opinion against the defamation of religious symbols, Quran burning, and Islamophobia-driven incidents. Through strategic use of its political influence, represented by its 57 member states, the OIC has generated significant legal and human rights momentum within the United Nations and its Human Rights Council. This has led to the adoption of several international resolutions that criminalize the defamation of religions and attacks on Islamic sanctities and symbols. This article examines the OIC’s efforts in securing the adoption of UN Resolution 35/16, the international controversy it sparked, and the subsequent replacement with the landmark Human Rights Council Resolution 18/16. It also explores the launch of the Istanbul Process, aimed at implementing the provisions of this resolution, and the OIC’s continued progress culminating in Resolution 53/1. Through these efforts, the OIC has solidified its achievements in defending religious freedom and the right to practice religion free from stereotypes and oppression, while also highlighting Islamophobia, which has recently become a top priority for the organization. The article employs an analytical method to investigate the topic’s scientific material, identifying both the successes and shortcomings of the OIC in this critical area.