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Vitiligo and Autoimmunity

Name: Vitiligo and Autoimmunity
Keywords: vitiligo, vitiligo, autoimmunity, antinuclear antibodies, thyroid peroxidase antibodies, Adult, Male, thyroid peroxidase antibodies, autoimmunity, Vitiligo, Reproducibility of Results, Autoimmunity, Skin Pigmentation

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2013 Croatia Publisher:ScopeMedJournal:Medical Archives, volume 67, page 91 (issn: 0350-199X,

Authors: Tomica Jukic; Emina Kasumagic-Halilovic; Begler Begovic; Nermina Ovcina-Kurtovic; Jasenko Karamehic; Sladjana Samardzic;

doi: 10.5455/medarh.2013.67.91-93

pmid: 24341051

Vitiligo and Autoimmunity

- Summary
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Abstract

Vitiligo is an acquired skin disorder characterized by depigmented maculae resulting from a reduction of the number and function of melanocytes. The etiopathogenesis of the disease is still unclear, but there is evidence that autoimmunity may be involved.The aim of this study was to determine the prevalence and significance of antinuclear (ANA) and thyroid peroxidase (anti-TPO) antibodies in patients with vitiligo and control group.In a prospective case-control study, we compared the frequency of antibodies (ANA and anti-TPO) in 40 patients with vitiligo and in 40 healthy volunteers.ANA were positive in 7 (17%) patients, which was insignificantly higher than control group, 2 (5%). Anti-TPO were positive in 11 (27%) patients. In control group, only two subjects (5%) had positive anti-TPO. Compared with the control group, the frequency anti-TPO were significantly higher in those with vitiligo (p < 0.05).Our findings show a significant association between vitiligo and thyroid autoimmunity, and that tests to detect anti-TPO are useful markers in patients with vitiligo. In contrary, ANA seems to have limited diagnostic relevance in routine clinical practice. Additional studies of a wider sample are warranted to confirm these findings and allow a detailed analysis.

Country

Croatia

Related Organizations

University of Sarajevo
Bosnia and Herzegovina
Clinical Center University of Sarajevo
Bosnia and Herzegovina
Josip Juraj Strossmayer University of Osijek
Croatia

Keywords

vitiligo, vitiligo, autoimmunity, antinuclear antibodies, thyroid peroxidase antibodies, Adult, Male, thyroid peroxidase antibodies, autoimmunity, Vitiligo, Reproducibility of Results, Autoimmunity, Skin Pigmentation, antinuclear antibodies, Middle Aged, Autoantigens, Iodide Peroxidase, Severity of Illness Index, Antibodies, Antinuclear, Case-Control Studies, Iron-Binding Proteins, Humans, Female, Biomarkers

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	21
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%