In this work, a trial was conducted to improve sheep reaction of the immune system to the inactivated FMD vaccination by using Zylexis as an immune-modulatory. Three groups of five sheep each were formed from the fifteen sheep. The first group received 2 injections of zylexis (2 ml/sheep, I/M) given on three days interval concurrently with vaccination with one dose of the inactivated FMD (SAT-2) vaccine (1ml/sheep, S/C); the second group got the vaccination and nothing else, while the third group served as a control and did not get any inoculation at all. To evaluate the humeral immune response, SNT and ELISA were used to serum samples, and blood samples obtained while taking heparin as an anticoagulant to assess the cellular immune response. Over the course of 40 weeks after vaccination, the findings showed that sheep given the inactivated zylexis vaccine had a stronger cellular and humoral immune response than sheep given the inactivated FMD (SAT-2) vaccine alone. In order to prolong the duration of immunity, it might be suggested to combine it with FMD vaccination. This would boost the immunological response of vaccinated animals.