With the development of human society, technology and medicine have been widely discovered. Bisphenol A (BPA) is a kind of substance widely used in industrial production, mainly used in the production of polycarbonate, epoxy resin and other polymer materials. Many analogues of BPA like BPS, BPF and BPAF have been used as substitutes for BPA. However, BPA and its analogues exposure in daily life has been found to be harmful to people's health. In this paper, the toxicity of BPA and its analogues in the environment exposed with different concentrations, exposure time, ages, genders has been discussed. In addition, the effects of BPA and its analogues on biological endocrine system, immune system, reproductive system and nervous system have been introduced by studying the endocrine organs of animal models. Results reveal that DNA can be severely damaged at certain BPA concentration, and that BPA may act directly on the ovary due to its similar structure to secreted estrogen Besides, BPA exerts a bi-directional regulatory effect on the mouse immune system, and when exposed to BPA for a long time, activity of immune system can be suppressed. Researches on BPA and its analogues’ effects on organs and systems can give some suggestion on the use as materials for the production.