2022 International Conference on Mathematical Modelling and Machine Learning (MMML 2022) was successfully held during 26-27 November, 2022 in Sydney, Australia. The conference intends to invite worldwide famous scientists, experts, scholars, and researchers for academic presentations. MMML 2022 aims to bring together leading experts and scholars in the fields of mathematical modeling and machine learning to share their experience and research results. It also provides an excellent interdisciplinary platform for researchers, practitioners and educators to showcase the latest innovations, trends and concerns in these fields, as well as practical challenges encountered and adopted solutions. This conference cordially invites high-quality research contributions to describe original and unpublished results of experimental or theoretical work in mathematical modeling and machine learning for presentation at conferences. Less than 60 articles were selected from more than 90 submissions after peer-review. Authors participated in MMML 2022 with oral presentations and posters, promoting the communication among researchers and experts from institutes and universities. Organizing Committee of MMML 2022 Sydney, Australia