Drug safety is related to people's livelihood and public safety. Therefore, we must improve drug supervision and curb the circulation of counterfeit and substandard drugs.At present, most of the centralized drug supervision systems have some problems, such as few participants, easy data tampering, lack of credibility and so on.This paper analyzes the application feasibility of blockchain technology in the field of drug supervision, and designs a decentralized drug supervision system based on Fisco Bcos blockchain, which can solve the problems of data forgery, data tampering, centralization and lack of trust in the current drug supervision system, and provide support and reference for all links of drug circulation.