For the intricate regulation of spatio-temporal patterns of Ca2+ signalling, intracellular Ca2+ stores play extremely important roles. Ca2+ stores are equipped with two classes of related Ca2+ release channels, the ryanodine receptor (RyR) and the inositol 1, 4, 5-trisphosphate receptor (IP3R). The RyR functions as a Ca2+ signal amplifier by receiving information form the L-type Ca2+ channels on the surface membrane and inducting the release of Ca2+ from the striated muscle sarcoplasmic reticulum. The IP3R is often involved in the generation of Ca2+ wave, which seems to be the results of regenerative Ca2+ release due to Ca2+ dependence of the IP3R activity. The activation of the IP3R often results in the generation of Ca2+ oscillation, which is implicated in the regulation of efficacy and specificity of Ca2+ signalling. With the advent of Ca2+ imaging technique and the employment of various molecular biological strategies, the mystery of Ca2+ signalling is now being unraveled.