We reviewed a sensing system and mechanism of bitter and odorous compound by using a lipid-coated quartz-crystal microbalance. Strength of bitter taste and odorant can be explained by the adsorption amount to a lipid matrix : the stronger bitter or odorous compound absorbs into the lipid membrane with the larger amount. This adsorption behavior can be explained by hydrophobicity and molecular shape of additives : the more hydrophobic and the more slender molecule absorbs into the lipid matrix with the larger amount.These adsorption behaviors can be applied for other bioactive compounds such as anesthetics, antibiotics, and hydrophobic drugs.