Recent progresses in the researches on the protein sorting in the intracellular traffic are reviewed.In the introduction the regionality of the plasma membrane is emphasized. The present concept of intracellular traffic is historically traced in the light of Bennett's idea of “membrane flow” (1956) and the “vesicular transport” hypothesis of Palade (1953).The organizational characteristics of Golgi apparatus (GA) is reviewed and its assumed role in the intracellular traffic is discussed. The signal sequences and their possible relations with the sorting mechanism are speculated on. The role of GA as a sorting machinery is questioned. Some of possible advances in researches in this discipline are predicted.