We report a unusual case of hydro-ureteronephrosis caused by schistosomiasis in a 66-year-old female. Computed tomography (CT) and biochemistry initially suggested a transitional cell carcinoma of the left proximal ureter. The patient was referred for reno-ureterectomy, but histopathological examination of the resection specimen demonstrated deposits of Schistosoma haematobium eggs. Although schistosomiasis is rare in Western Europe, this case illustrates the importance of considering infectious disease in patients with obstructive uropathy, particularly in the context of travelling or immigration from endemic areas.