Molecular Diagnostics in Periprosthetic Joint Infection
Copyright policy )Molecular Diagnostics in Periprosthetic Joint Infection
Periprosthetic joint infection (PJI) is a significant and costly challenge to the orthopedic community. The lack of a gold standard for diagnosis remains the biggest obstacle in the detection and subsequent treatment of PJI. Molecular markers in the serum and joint fluid aspirate hold immense promise to enhance the development of a firm diagnostic criterion. The primary goal is one marker with high sensitivity and specificity. Here, we review our current research efforts in the field of molecular markers: C-reactive protein, erythrocyte sedimentation rate, white blood cells, and leukocyte esterase. Each marker has been studied to determine its sensitivity, specificity, and positive and negative predictive values in diagnosing PJI.
- Thomas Jefferson University United States
- Thomas Jefferson University Hospital United States
leukocyte count, esterase, Joint Prosthesis, Joint arthroplasty, Synovial fluid aspirate, synovial fluid, Synovial Fluid, Rothman Institute, Philadelphia, receiver operating characteristic, C reactive protein, periprosthetic joint infection, predictive value, Periprosthetic join infection, article, 600, Prognosis, C-Reactive Protein, Molecular Diagnostic Techniques, Leukocyte esterase, debridement, infectious arthritis, Prosthesis-Related Infections, review, 610, 9007-41-4, Blood Sedimentation, wound irrigation, Sensitivity and Specificity, C-reactive protein, Predictive Value of Tests, molecular diagnosis, Humans, human, joint aspiration, molecular marker, leukocyte enzyme, 9013-79-0, prosthesis infection, Pennsylvania, United States, enzyme linked immunosorbent assay, joint prosthesis, Thomas Jefferson University Hospital, Orthopedics, sensitivity and specificity, arthroplasty, erythrocyte sedimentation rate, Carboxylic Ester Hydrolases, Biomarkers
leukocyte count, esterase, Joint Prosthesis, Joint arthroplasty, Synovial fluid aspirate, synovial fluid, Synovial Fluid, Rothman Institute, Philadelphia, receiver operating characteristic, C reactive protein, periprosthetic joint infection, predictive value, Periprosthetic join infection, article, 600, Prognosis, C-Reactive Protein, Molecular Diagnostic Techniques, Leukocyte esterase, debridement, infectious arthritis, Prosthesis-Related Infections, review, 610, 9007-41-4, Blood Sedimentation, wound irrigation, Sensitivity and Specificity, C-reactive protein, Predictive Value of Tests, molecular diagnosis, Humans, human, joint aspiration, molecular marker, leukocyte enzyme, 9013-79-0, prosthesis infection, Pennsylvania, United States, enzyme linked immunosorbent assay, joint prosthesis, Thomas Jefferson University Hospital, Orthopedics, sensitivity and specificity, arthroplasty, erythrocyte sedimentation rate, Carboxylic Ester Hydrolases, Biomarkers
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