Amavata is a disease caused by vitiation of Vata Dosha associated with formation of Ama (bio-toxin). The Ama combines with Vata Dosha and occupies Sleshmasthana (Asthisandhi) which results in Amavata, producing symptoms like stiffness, swelling and pain in the joints. Amavata is compared with Rheumatoid Arthritis (RA) based on similarities in sign and symptoms. RA is a chronic progressive disease causing inflammation in the joints and resulting in painful deformity and immobility, especially in the fingers, wrists, feet and ankles. The prevalence of Rheumatoid arthritis is approximately 0.8 % of the population (range 0.3 to 2.1%) women are most commonly affected. CASE PRESENTATION: We report the case of a 20 years old female patient experiencing pain in multiple joints along with swelling and stiffness. Patient was investigated with markedly raised level of bio-markers like R.A. Factor, E.S.R., C-Reactive Protein (CRP) and Anti-cyclic citrullinated peptide (anti-CCP) antibody. The patient was administered various Shaman, Deepana and Ama-paachanyogas along with Balukaswedan. The symptoms of Amavata (RA) like Sandhi ruja (joint pain), Sandhishotha (joint swelling) Stabdhata (morning stiffness), and tests like R.A. Factor, ESR, CRP and Anti-CCP were observed over the treatment. Marked improvement were observed in signs and symptoms of Amavata during the course of treatment. Patient was feeling much better than earlier and she felt that about >95% of her symptoms got decreased. No any complication was found during the treatment.