Introduction: Third molar surgeries are the most commonly practiced surgeries in the dental office. The incidence of surgical site infection is still higher in spite of antibiotic prophylaxis owing to the need for the use of alternative measures. Antibacterial sutures are recently being used following third molar surgeries to reduce the incidence of surgical site infections and inflammatory sequels. Objectives: To assess vicryl plus sutures in comparison with conventional plain vicryl in various parameters like swelling, infection, trismus, erythema and pain. Methods: Total of thirty patients having bilateral impacted mandibular third molars were selected. Plain vicryl was used for primary closure after disimpaction on the former side (Group A) and vicryl plus containing triclosan for the same on the contralateral side (Group B). Swelling, trismus, erythema, infection and pain were compared between the groups consecutively on 3rd, 7th, 15th days and one month. The observations and results were compiled. Results: The study yielded significant statistical results in terms of trismus, pain and erythema although the numerical significance was seen in all parameters. Conclusion:Vicryl suture containing triclosan was comparatively more effective in reducing the post-surgical sequel after third molar surgery than conventional plain vicryl suture.