Migraine is an episodic headache sickness generally characterised by route of ache regarding both 1/2 of the head. according to global headache society, Migraine constitutes sixteen% of the primary headache and influences approximately 10-20% of the general population. Ardhavabhedaka is mentioned beneath Shiroroga (diseases of head) which can be correlated with migraine. Nasya Karma is considered because the excellent healing intervention in Shiro Roga by using Acharya Charaka. Kumkumadi Ghrita is noted via Acharya Vagbhata in context of Shiroroga Chikitsa. So, an attempt has been made to assess the efficacy of Anu Taila Nasya within the management of migraine in this unmarried case take a look at. After 7 days of Nasya Karma, tremendous development became seen in the scientific capabilities of Migraine. Materials and Methods: The subject who approached Shalakya Tantra OPD of Shalakya Tantra, Ashwin Rural Ayurved College, Sangamner, Ahmednagar with symptoms of Migraine since 2 years was systemicallyreviewed and Nasya line of treatment is adopted. Results: The subject showed marked improvementas depicted in the scoring scale before and after treatment. Discussion: By adopting the holisticapproach with both internal and external treatment modalities an attempt is made to bring aboutsatisfactory results.