Background and Objective: Poisoning is a common medico-social problem worldwide. Its pattern and outcome varies from place to place causing significant morbidity and mortality.Hence this is an attempt to study the profile of common poisonings and its outcome inour tertiary-care hospital. Materials and Methods: This is a cross-sectional observational study. we studied 100 admitted poisoning patients in Krishna Rajendra hospital, Mysore who met the inclusion and exclusion criteria .The demographic data, compound details, its complications and outcome were analyzed. Results: In this study most of them were in the age group of 21-30years(37%),76 % were males and 24% were females. Majority of them were married(74%),48% were illiterate, 80% were from rural areas with lower socioeconomic status(65%).The most common poisoning was Non-Organophosphorus compound –Cypermethrin(35%).(20% )Organophoshorus compound,(15%)aluminum phosphide,(12%) multiple tablets,(7%) unknown,(4%)paraquat,(4%)Ratpowder,(2%)Rat paste,(1%)acid ingestion. Majority were suicidal (88%),13% had ICU admissions and 11%died. Conclusion: In this study pesticides were the most common poison leading to significant mortality ,with majority of them being suicidal.Hence there is a need for stringent pesticide regulation laws and suicidal prevention awareness in the society.This study also emphasizes the need of psychological counseling and mental health training programs to the targeted population to reduce the incidence of suicidal poisoning.