Acute pancreatitis is an inflammatory condition marked by localized tissue damage that may lead to a broader inflammatory reaction. There is growing evidence that patients with a severe form of acute pancreatitis have endothelial dysfunction as one of the key pathophysiologic symptoms. In line with this, there have been new studies linking acute pancreatitis to the hematological condition thrombotic thrombocytopenic purpura (TTP).Here, we are describing a rare conversive event in which severe pancreatitis led to thrombocytopenic purpura.