Introduction:Thyroid nodules are common entities presenting to the surgical outpatient department. They are defined as A discrete swelling in an otherwise impalpable gland. Incidence of malignancy has been observed to be quite high in solitary thyroid nodules. Thus, they have to be evaluated properly for optimum management. Aim of the study is to identify the incidence of malignancy in solitary nodule thyroid. Materials and Methods:This study was a prospective non-randomized hospital based interventional study carried out on 50 patients who presented clinically with solitary thyroid swellings who thereby underwent surgery for the disease from August 2020 to July 2022 at the Department of General surgery of our institute. Results:There were 50 cases of clinically detected solitary thyroid nodule with female preponderance more than males. The mean age of the incidence of solitary thyroid nodule was 40.6 years. The incidence of malignancy in solitary thyroid nodule was found to be 18%. Conclusions:It is concluded from the present study that 18% of solitary thyroid nodules are malignant, with female preponderance and a mean age of solitary thyroid nodule is 40.62 years.