Background And Objectives:-Acid peptic disease comprises of a wide spectrum of diseases, which cause considerable morbidity. Helicobacter pylori, a curved rod-shaped bacterium, has been consistently associated with patients suffering from acid peptic diseases, more in ulcer disease than in non-ulcer disease. Due to this high association, it is now believed that helicobacter pylori plays an important role in the aetiopathogenesis of acid peptic disease. Methods:We Have Attempted To Study The Prevalence Of H.Pylori In Patients Undergoing Upper GI Endoscopy In Patients With Dyspepsia At Our Pes Hopital(Pesimsr) ,Kuppam,AndhraPradesh. Results:-Total Of 100 Upper Gastro Intestinal Endoscopies Were Performed And Biopsies Were Taken During The Study Period In Which Males Were More Infected With H.Pylori Infection In The Age Group Of 31-50 Years . Conclusion:-The Burden Of H.Pylori Infection Among Dyspeptic Patients Was High.There Is Limited Access To Endoscopic Services And Widespread Prior Antibiotics as Empirical Treatment.