Vaginal melanomas are extremely rare gynaecological malignancy and very aggressive tumor. There is no standardized treatment owing to the extreme rarity of the disease. The prognosis of vaginal primary melanoma is very poor despite treatment modality, because most of the cases are diagnosed at advanced stage. This paper details the clinical course of 2 patients with primary vaginal melanoma treated by definitive radiation therapy, this report includes also a summary of available treatments of this uncommon disease, with focus on the role of radiotherapy.