Background: SARS-CoV-2 infection are quite diverse, ranging from asymptomatic disease to pneumonia and potentially fatal consequences. The use of routine blood investigation parameters as a marker of disease severity will results in improved clinical awareness to identify the target patients at higher risk. This study aimed to evaluate haematological profile in COVID-19 patients in relation with outcome test in Covid 19 positive patients. Objective: To study hematological profile in COVID-19 patients in relation with prognosis and outcome. Material & Methods: The present hospital based cross sectional observational study carried among total sample size of 384 patients aged 12 years and above who have SARS-CoV-2 infection confirmed by reverse transcriptase–polymerase- chain-reaction assay and/or Rapid Antigen test and admitted in medicine ward at tertiary care centre during Jan 2021 to Dec 2022. The study was conducted after obtaining clearance from the Ethical Committee of the institute. Patients with haematological malignancies and hemoglobinopathies like thalassemia and sickle cell disease were excluded. Data of each patient was collected in special proforma which includes clinical manifestations and laboratory values. Results: The mean age of the study population was 42.50 ±10.94 years with male predominance. (63.28%). Among 384 patients, 102 (26.56%) patients were having anaemia. Low MCV in 48.17%, while N/L ratio was >3.53 in 165 (42.96%) patients. It has been seen that there was statistically significant relation between the mean values of Surviours and non-surviours with respect to RDW, TLC, NLR and Platelets. Conclusion: The present study concludes that laboratory parameters like RDW,MPV, Platelet count, Total leucocyte count ,Neutrophils count ,Lymphocytes count, N/L ratio can be considered as early prognostic markers of COVID 19 disease.