Background: The aim of the present study was to evaluate the efficacy of demineralized freeze-dried bone allograft with and without Melatonin for socket preservation based on clinical, radiological and histological parameters. Methods: A total of 20 single-rooted teeth indicated for extraction were included in this randomized controlled clinical study of 6 months duration. The subjects were allocated into two groups for socket preservation viz. test group (DFDBA with Melatonin Powder) and control group (DFDBA only) randomly with the toss of coin.Clinical,radiological and histological parameters were recorded at baseline and 6 months. Results: Both the groups showed comparable results in clinical, radiographic and histological parameters with considerable promise of regeneration, thus can be used in maintaining the ridge width and height post extraction. Conclusion: It be concluded that DFDBA with or without melatonin can be used for socket preservation with predictable and comparable results. No significant advantage of mixing melatonin with DFDBA was observed in our study. However, further studies with larger sample size and use of melatonin with other bone grafts should be conducted to ascertain the findings of our study.