Aim: An observational cross sectional study for assessing the levels of High sensitivity creactive protein in patients with acute coronary syndrome and study its prognostic implication. Methods: All the patients presenting with clinical,ECG and 2D – echocardiographic evidence of acute myocardial infarction admitted in department of medicine. Results: A study of 48 patients with acute coronary syndrome of both sex were taken as sample.36 patients were diagnosed as ST elevation MI(STEMI) and 12 patients were diagnosed as Non-ST elevation MI(NSTEMI).Out of 36 STEMI patients,20 patients were male and 16 were female.Out of 12 NSTEMI patients,6 were male and 6 were female.Among male patients with STEMI ,85% had risk factor of smoking,alcohol,diabetes mellitus or systemic hypertension,whereas in females it was 81%.Among NSTEMI males had risk of 83% and females it was 60%.In patients with STEMI,8% had normal EF,25% had Moderate EF and 50% had low EF.The correlation between the prognosis and values of HS-CRP of patients with extensive AWMI is found to be statistically significant.(ppatients with extensive AWMI is found to be statistically significant.(p<0.05). Conclusion: The levels of HS-CRP correlate with several cardiovascular risk factors such as smoking,diabetes mellitus and hypertension.Elevated levels of hs-CRP is related to the presence of plaque rupture ,which provokes acute coronary syndrome.Therefore, in a resource limited country like India, evaluation of hs-CRP would be considered as the best modality over optical coherence tomography and intravascular ultrasound.This suggests that the assessment of HS-CRP levels may enable the physician in detecting the prognosis of acute coronary syndrome patients,plan effective reperfusion therapy and also assess long term complications.