TRANSFORM project provides regional public authorities and other interested R&I actors with inspiring examples and practical suggestions, emerging from real regional settings and experimentations, on how to implement RRI principles through sound methodologies to engage citizens and multiple stakeholders. This Policy Brief outlines recommendations for policymakers committed to transforming regional R&I systems towards RRI by implementing participatory approaches. These recommendations are grounded in the lessons learned by project partners in implementing the three cluster activities (Lombardy – Italy; Catalonia - Spain; Brussels-Capital Region - Belgium), shared learning, and monitoring actions. Each of the regions participating in TRANSFORM has experimented with different participatory methodologies that, as expected, have had an effect on other parts of their R&I regional governance structure.