Bhallataka is a toxic drug which comes under Upavisha Varga according to classical texts in Rasashastra. But its have so many properties, that makes it to use in various diseases. Ashuddha Bhallataka can cause the toxic effects but when it goes under the Samskara i.e. Shodhana procedure it plays important role in therapeutic values. Due to the presence of Tarry oil which when comes in direct contact to the skin it forms the blisters, itching and all other side effects to the body. So, there are the fear factors when to deal with toxic drugs. Specially the precautionary methods which should be follow and the knowledge of antidots for the particular one. Different Acharya have mentioned various Shodhana methods for the Bhallataka with different media. Media plays a very important role in reducing the toxicity and with particular media enhancing its properties. So, in this study an attempt has been done for Shodhana of Bhallataka by taking all the precautionary and observation study being made to reduce the errors in further.  Aim: To do the Pharmaceutical study for Shodhana of Bhallataka.  Material and Methods: Ashuddha Bhallataka was taken from Sundar Ayurveda Pharmacy, Nadiad. Shodhana Procedure was done according to the reference mentioned in Rasatarangini. Narikela Jala and Godugdha were used as media. All the equipments and precautions were taken during the procedure.  Results: Yield of Shuddha Bhallataka after Shodhana with both media was 52.9 % . After so many precautions still it showed the toxic effects itching all over body and red patches all over the skin.  Conclusion: So, this study deals with the parameters used in the pharmaceutical study from which you can get the idea how to do it as per the classical text and can get the Shuddha Bhallataka . Also precautionary methods to be followed and if there are toxic effects so how we can overcome to them.