Twak is a link between internal and external environment and is also the seat of complexion, which maintains beauty and personal identity in the society. About more than 90% of total woman populations are affected by stretch marks on the body particularly on the abdomen, groin and on the chest region during and after pregnancy, which remains rest of life. Kikkisa is a type of skin ailment that occurs during pregnancy and mentioned in the disorders of pregnancy by the various Acharyas. An attempt is made to evaluate clinical efficacy of Chandanadi Shatadhaut Ghrita in 30 patients of Kikkisa. Though Kandu is a symptom of Kapha but here in Kikkis Kandu is due to dryness of skin. So Kandughna action of Tikta Rasa and Snehana effect of Snigdha Guna protect and give relief from Kandu. Tikta Rasa and Katu Vipaka have Kandughna property that helps to reduce Kandu and also Chandana and Karanaj area Kandughna drugs. Tikta and Kashaya Rasa have Daha Shamak property whereas chandan and ushira also have Pittashamak property, which reduce the Vidaha. Tikta Rasa and Katu Vipaka have Kushthaghna property and ushira and chandan have Varnya action. Kandu, Vidaha and Vaivarnyata were reduced markedly after the treatment of Kikkisa with chandanadi shatadhaut ghrita. There was no effect was seen of the chandanadi shatadhaut ghrita on reduction of the area of Kikkisa lesion. No any untoward effect was noticed during follow up study.