Background: By 2050, Indias 60 and older population is expected to encompass 323 million people, a number greater than the total US population in 2012. Osteoarthritis is the growing cause of social and economic burden to our aging society. It has been seen psychosocial status of patient with osteoarthritis have an impact on pain, functional ability and quality of life. The emotional status of osteoarthritis patient can have poor outcome on his/her Quality of life making the person disabled in their activities and functions. The majority of osteoarthritis pharmacological and rehabilitation treatments are geared toward alleviating pain due to disease severity in the joint therefore, it appears important to optimize treatment for people who have pain beyond peripheral sources. Objective: This study will help to understand the association of emotional status, pain, radiographic severity and quality of life in patients with knee osteoarthritis so that a more holistic approach will be developed towards osteoarthritis. Methodology: Study design was a cross sectional observational study. 100 subjects were assessed in the study. Participants were included in the study after screening for inclusion and exclusion criteria. All subjects were evaluated according to the assessment proforma for the following Pain on Visual Analogue Scale (VAS), Positive And Negative Affect Scale and Knee function on Knee Injury and Osteoarthritis Outcome Score (KOOS). Conclusion: The findings of this study suggest an association between emotional status and pain, emotional status and quality of life. But no association is seen between emotional status and Kellgren Lawrence Scale.