Objective(s): The current studys goal is to develop and test a tramadol hydrochloride transdermal gel based on vesicular drug delivery approaches. Materials and methods: Transferosomes were chosen as the colloidal carrier for tramadol hydrochloride transdermal gel preparation. Thin film hydration was used to create transferosomes. The obtained transferosomes were characterised for drug content, vesicular diameter, zeta potential, entrapment efficiency, invitro drug release studies. Results: T5 (made via thin film hydration and comprising a soya lecithin: Tween 60 ratio of 1:2.5) was deemed the best transferosome formulation due to its 274.2nm mean vesicular diameter, -29.5 mV zeta potential, 93.9% drug content, 97% entrapment efficiency, and 92.7% sustained drug release after 12 hours. The T5 formulation was included into the gel. There was a comparison between plain gel and transfersomal gel. Transfersomal gel was rated superior to the other gels due to its higher drug concentration (91%), spreadability (18.35 g.cm/sec), pH (6.9), and sustained drug release profile over 12 hours. Conclusion: By comparing transferosomal gel with plain gel transferosomal gel indicated better results than plain gel.