Acute pancreatitis is a rare presentation of Primary hyperparathyroidism (PHPT), its prevalence during PHPT is about 1%. The physiopathology of the implication of PHPTs hypercalcemia is not completely elucidated. Several hypotheses plead for the direct or indirect role of hypercalcemia via the activation of pancreatic proteases. Acute alithiasic pancreatitis can be a revealing feature of PHPT wich is a curable disease with the mastery of parathyroid surgery and hypercalcemia treatment. Herein, the authors report a rare case of a patient with PHPT revealed by acute alithiasic pancreatitis with a dreaded complication.