Firstly,we are study to formulate and test a topical gel containing of Itraconazole micro- emulsion (ITZ). The Formulation of micro emulsion researchis necessary to study before its thepreformulation study of micro emulsion of Itraconazole. To estimatethe maximal solubility of ITZ in oils, surfactants and co- surfactants were investigated to estimatefilling material potential. In reference to the micro- emulsion region, with Karanj oil as the oil phase, the use of surfactant as a Tween-80 and use as aDiamethyl Carbinol Or (IPA) as the Another surfactant to improve its performance, a pseudo- ternary phase diagram was created. If using of Carbopol 934, Xantumgum, carboxymathylcellulose,Carboxymethyl -Tamarind gum (CMTG (CMC) That may be increased or improved its qualitative & Quantitative test .ME is evaluate by % transmittance, Viscosity, pH,particle-Size, zeta potential, Physical appearance, Drug content, pH,spreadability, viscosity, in -vitro release. If we take a oil as like karanj oil in the form of oil phase and using of a surfactant as like Tween 80 that may be obtain -Stable ME & useco-surfactant as an IPA, the weight ratio of 5:45:50. The evaluate ME based gel which is pH range between in (6.0- 6.34),and the Spreadability rangeis between (0.56-1.06) gm.cm/sec. The consistency or viscosity examination intimated pseudo- plastic performance of all ME based gel formulations.In the midest the examination ME gels If we are using of CBP: CMTG containing gels that may be we obtain greater maximum drug release at the end of 6h incomprising to other marketed.